Puberty Blockers and Cross Sex Hormones

From Mayo Clinic:

Possible side effects of GnRH analogue treatment (puberty blockers) include:

  • Injection site swelling
  • Weight gain
  • Hot flashes
  • Headaches

Use of GnRH analogues might also have long-term effects on:

  • Bone density
  • Future fertility

If children with male genitalia begin using GnRH analogues early in puberty, they might not develop enough penile and scrotal skin for certain gender confirmation genital surgical procedures, such as penile inversion vaginoplasty. Alternative techniques, however, are available.

In addition, delaying puberty beyond one’s peers can be stressful. Your child might experience lower self-esteem.

From Gender Dysphoria Alliance Canada (GDAC), an evidence-based education & advocacy network:

In some cases of severe Gender Dysphoria, medical treatments to change the appearance of our bodies can be helpful. These treatments can not change your biological sex, but they can masculinize or feminize your appearance, which is helpful for some people. This is a big decision. A medical transition is a very complex physical, social and psychological change, which can be extremely stressful. There are risks as well as benefits – which aren’t entirely predictable. 

Masculinizing Hormones Fact Sheet

Feminizing Hormones Fact Sheet

​Please talk to your doctor for more information. 

From the National LGBTQIA+ Education Center:

More information on medication risks can be found in this PDF on relevant medical and psychological aspects of transitioning while receiving treatment with hormones:

Cross-Sex Hormone Therapy

The Trevor Project is the leading national organization providing crisis intervention and suicide prevention services to lesbian, gay, bisexual, transgender, queer & questioning youth.

Illuminating Case History

In this intimate interview, Dominic Lauren opens up about what attracted her to a trans identity and how, among other things, hormones affected her mental health resulting in a cascade of polypharmacy with psychotropic medications.